Just adding my two cents. Ryan is really good with this stuff.
Yes you do have to increase additional network memory. If your OS has enough memory you should be good. If you have older application you will probably want to increase the packet size so your not flooding the network.
I do know there was an issue with ssl (doesn't matter if it's certicom or openssl). When you have large amount data going through with one process or a long running process that runs for hours it can have problems. This issue is fixed in SDK 15.7 SP132 and ASE 15.7 SP132 when they come out.
Thanks,
Dawn